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D-Dopachrome Tautomerase (DDT)

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DDCT; D-Dopachrome Decarboxylase; Phenylpyruvate tautomerase II

D-Dopachrome Tautomerase (DDT)
CCC D777
HGNC 2732
MGI 1298381
RGD 61923
UniProt P30046
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.
Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely linked on human chromosome 22 and mouse chromosome 10.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD777Hu01 Recombinant D-Dopachrome Tautomerase (DDT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD777Hu01 Polyclonal Antibody to D-Dopachrome Tautomerase (DDT) WB; IHC; ICC; IP.
LAD777Hu71 Biotin-Linked Polyclonal Antibody to D-Dopachrome Tautomerase (DDT) WB; IHC; ICC.
MAD777Hu21 Monoclonal Antibody to D-Dopachrome Tautomerase (DDT) WB; IHC; ICC; IP.
Assay Kits SED777Hu ELISA Kit for D-Dopachrome Tautomerase (DDT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD777Mu01 Recombinant D-Dopachrome Tautomerase (DDT) Positive Control; Immunogen; SDS-PAGE; WB.
RPD777Mu02 Recombinant D-Dopachrome Tautomerase (DDT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD777Mu01 Polyclonal Antibody to D-Dopachrome Tautomerase (DDT) WB; IHC; ICC; IP.
PAD777Mu02 Polyclonal Antibody to D-Dopachrome Tautomerase (DDT) WB; IHC; ICC; IP.
Assay Kits SED777Mu ELISA Kit for D-Dopachrome Tautomerase (DDT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant D-Dopachrome Tautomerase (DDT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to D-Dopachrome Tautomerase (DDT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to D-Dopachrome Tautomerase (DDT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for D-Dopachrome Tautomerase (DDT) CLIA Kit Customized Service Offer
n/a ELISA Kit for D-Dopachrome Tautomerase (DDT) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation."Biochem. Biophys. Res. Commun. 243:538-544(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF."Mamm. Genome 9:753-757(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution."Biochemistry 38:3268-3279(1999) [PubMed] [Europe PMC] [Abstract]