Adenosine Thiamine Diphosphate (AThDP)

Adenosine thiamine diphosphate (AThDP), or thiaminylated adenosine diphosphate (ADP) is a natural thiamine adenine nucleotide. It was chemically synthesized and exists in small amounts in vertebrate liver. Its biological significance remains unknown.

Thiamine or thiamin (pronounced "THIGH-a-min"), and named as the "thio-vitamine" ("sulfur-containing vitamin") is a water-soluble vitamin of the B complex. First named aneurin for the detrimental neurological effects of its lack in the diet, it was eventually assigned the generic descriptor name vitamin B₁. Its phosphate derivatives are involved in many cellular processes. The best characterized form is thiamine pyrophosphate (ThDP), a coenzyme in the catabolism of sugars and amino acids. In yeast, ThDP is also required in the first step of alcoholic fermentation.