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Topoisomerase II Beta (TOP2b)

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TOPIIB; Top2beta; DNA topoisomerase II, beta isozyme

Topoisomerase II Beta (TOP2b)
CCC D798
HGNC 11990
MGI 98791
PubMed 20601956
UniProt Q02880
Wiki TOP2B
DNA topoisomerase 2-beta is a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD798Hu01 Recombinant Topoisomerase II Beta (TOP2b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD798Hu01 Polyclonal Antibody to Topoisomerase II Beta (TOP2b) WB; IHC; ICC; IP.
MAD798Hu21 Monoclonal Antibody to Topoisomerase II Beta (TOP2b) WB; IHC; ICC; IP.
Assay Kits SED798Hu ELISA Kit for Topoisomerase II Beta (TOP2b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD798Mu01 Recombinant Topoisomerase II Beta (TOP2b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD798Mu01 Polyclonal Antibody to Topoisomerase II Beta (TOP2b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Topoisomerase II Beta (TOP2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Topoisomerase II Beta (TOP2b) ELISA Kit Customized Service Offer
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