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Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1)

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Pa; Pr; Db-s; PRP-1/PRP-2; Proline-Rich Protein HaeIII 1; Parotid double-band protein; Parotid isoelectric focusing variant protein; Parotid acidic protein; Parotid proline-rich 1/2

Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1)
CCC D811
HGNC 9366
MGI 97773
PubMed 3687941
UniProt P02810
Wiki PRH1
According to the hypothesis of Maeda, the 3 acidic PRPs, Db, Pa, and PIF, are coded for by alleles at a single locus rather than by 3 discrete loci. The hypothesis is based on DNA studies which suggest that 6 loci control the synthesis of the PRPs. Genes at 2 of these loci, PRH1 and PRH2 (so named because they contain repeated cleavage sites for the restriction enzyme HaeIII), code for the acidic PRPs. Genes at the remaining 4 loci (PRB1, PRB2, PRB3, and PRB4) contain regions that strongly hybridize to a probe with repeated BstNI sites; they probably code for the basic and glycosylated PRPs. This hypothesis of 6 loci forming 2 gene subfamilies contrasts with that based on protein polymorphisms in families that suggest 13 loci with 11 common null alleles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acidic Salivary Proline Rich Phosphoprotein 1 (PRH1) ELISA Kit Customized Service Offer
  1. "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system."J. Biol. Chem. 260:11123-11130(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family."J. Biol. Chem. 261:6712-6718(1986) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a possible precursor of a related salivary protein A."J. Biol. Chem. 255:5943-5948(1980) [PubMed] [Europe PMC] [Abstract]
  6. "Complete covalent structure of a proline-rich phosphoprotein, PRP-2, an inhibitor of calcium phosphate crystal growth from human parotid saliva."Int. J. Pept. Protein Res. 27:373-379(1986) [PubMed] [Europe PMC] [Abstract]
  7. "Alleles at the PRH1 locus coding for the human salivary-acidic proline-rich proteins Pa, Db, and PIF."Am. J. Hum. Genet. 41:1035-1047(1987) [PubMed] [Europe PMC] [Abstract]
  8. "The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f)."Biochem. J. 255:15-21(1988) [PubMed] [Europe PMC] [Abstract]
  9. "The complete primary structure of a proline-rich phosphoprotein from human saliva."J. Biol. Chem. 254:4800-4808(1979) [PubMed] [Europe PMC] [Abstract]
  10. "Complete primary structure of a proline-rich phosphoprotein (PRP-4), a potent inhibitor of calcium phosphate precipitation in human parotid saliva."(In) Gross E., Meienhofer J. (eds.);Peptides: structure and biological function (Proceedings of the 6th American peptide symposium), pp.133-136, Pierce Chemical Co., Rockford Il. (1979)
  11. "Primary structure of the active tryptic fragments of human and monkey salivary anionic proline-rich proteins."Int. J. Pept. Protein Res. 17:34-41(1981) [PubMed] [Europe PMC] [Abstract]
  12. "Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins."Proteomics 5:805-815(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C."J. Biochem. 87:1071-1077(1980) [PubMed] [Europe PMC] [Abstract]
  14. "Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual."Biochemistry 30:3351-3356(1991) [PubMed] [Europe PMC] [Abstract]
  15. "A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry."FEBS Lett. 475:131-134(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases."J. Biol. Chem. 283:19957-19966(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Finding new posttranslational modifications in salivary proline-rich proteins."Proteomics 10:3732-3742(2010) [PubMed] [Europe PMC] [Abstract]
  18. "A frequent mutation in the acidic proline-rich protein gene, PRH2, causing a Q147K change closely adjacent to the bacterial binding domain of the cognate salivary PRP (Pr1') in Afro-Americans."Hum. Mutat. 12:72-72(1998) [PubMed] [Europe PMC] [Abstract]