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Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2)

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Pr; Parotid Proline-Rich Protein; Proline-Rich Protein HaeIII Subfamily 2

Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2)
CCC D812
HGNC 9367
PubMed 10627138
UniProt P02810
Previously identified proline-rich proteins have some similarities to collagen and some to enamel protein. Identification of polymorphism stimulated search for an association between specific phenotype and oral disease.The genes are rich in HaeIII restriction sites; hence, the designation PRH1 and PRH2. Maeda (1985) concluded that what she terms PRH2 codes for Pr. HindIII restriction fragments of DNA from Chinese hamster x mouse somatic cell hybrids hybridized with cDNA clones of proline-rich protein only when the DNA was isolated from cells containing mouse chromosome 8 or a fragment thereof. PRP is near the centromere. In the mouse, polymorphism of the proline-rich proteins of saliva is demonstrated to have a relationship to taste. There was complete concordance between this marker and an RFLP in the 12q14-12q22 region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD812Hu01 Recombinant Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD812Hu01 Polyclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) WB; IHC; ICC; IP.
MAD812Hu21 Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) WB; IHC; ICC; IP.
MAD812Hu25 Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) WB; IHC; ICC; IP.
MAD812Hu23 Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) WB; IHC; ICC; IP.
MAD812Hu27 Monoclonal Antibody to Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) WB; IHC; ICC; IP.
Assay Kits SED812Hu ELISA Kit for Acidic Salivary Proline Rich Phosphoprotein 2 (PRH2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  15. "A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry."FEBS Lett. 475:131-134(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases."J. Biol. Chem. 283:19957-19966(2008) [PubMed] [Europe PMC] [Abstract]
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  18. "A frequent mutation in the acidic proline-rich protein gene, PRH2, causing a Q147K change closely adjacent to the bacterial binding domain of the cognate salivary PRP (Pr1') in Afro-Americans."Hum. Mutat. 12:72-72(1998) [PubMed] [Europe PMC] [Abstract]