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Proline Rich Nuclear Receptor Coactivator 2 (PNRC2)

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Proline Rich Nuclear Receptor Coactivator 2 (PNRC2)
CCC D815
HGNC 23158
MGI 106512
PubMed 23234702
UniProt Q9NPJ4
Wiki PNRC2
Coimmunopurification analysis and protein pull-down assays confirmed the interaction. PNRC2 preferentially interacted with hyperphosphorylated UPF1 and triggered movement of UPF1 into P bodies. Downregulation of PNRC2 impaired the localization of hyperphosphorylated UPF1 to P bodies. PNRC2 also interacted with DCP1A, a component of the decapping complex.
Downregulation of endogenous PNRC2 or UPF1 in HeLa cells via small interfering RNA abrogated NMD and increased the levels of COMMD7 and IARS mRNA, suggesting that these are natural NMD substrates. Furthermore, PNRC2 elicited mRNA degradation when tethered to RNA downstream of the normal termination codon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Rich Nuclear Receptor Coactivator 2 (PNRC2) ELISA Kit Customized Service Offer
  1. "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif."Nucleic Acids Res. 29:3939-3948(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma."Biochem. Biophys. Res. Commun. 312:975-982(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex."Mol. Cell 33:75-86(2009) [PubMed] [Europe PMC] [Abstract]