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Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2)

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PLC-IV; Phosphoinositide phospholipase C-gamma-2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2)
CCC D841
HGNC 9066
MGI 97616
PubMed 7774933
RGD 3348
UniProt P16885
Wiki PLCG2
Overexpressed wildtype rat Plcg1 or a lipase-inactive mutant Plcg1 each augmented ACE in rat PC12 cells, while a deletion mutant lacking the region containing the SH3 domain of Plcg1 was ineffective. RNA interference to deplete either Plcg1 or Plcg2 in PC12 and rat aortic smooth muscle A7r5 cells inhibited ACE. In chicken DT40 B lymphocytes expressing only Plcg2, overexpressed human muscarinic M5 receptors (M5R) activated ACE. Using DT40 PLC2 knockout cells, M5R stimulation of endoplasmic reticulum Ca(2+) store release was unaffected, but ACE was abolished. Normal ACE was restored by transient expression of rat Plcg2 or a lipase-inactive Plcg2 mutant. The results indicated a lipase-independent role of PLCG in the physiologic agonist-induced activation of Ca(2+) entry.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD841Hu01 Recombinant Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD841Hu01 Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) WB
MAD841Hu21 Monoclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) WB; IHC; ICC; IP.
Assay Kits SED841Hu ELISA Kit for Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) ELISA Kit Customized Service Offer
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  2. "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."BMC Genomics 7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling."J. Biol. Chem. 276:47982-47992(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of phospholipase Cgamma2 by tyrosine phosphorylation."Mol. Pharmacol. 62:672-679(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions." N. Engl. J. Med. 366:330-338(2012) [PubMed] [Europe PMC] [Abstract]
  11. "A hypermorphic missense mutation in PLCG2, encoding phospholipase Cgamma2, causes a dominantly inherited autoinflammatory disease with immunodeficiency."Am. J. Hum. Genet. 91:713-720(2012) [PubMed] [Europe PMC] [Abstract]