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Phospholipase C Eta 2 (PLCh2)

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PLCL4; PLCeta2; RP3-395M20.1; PLC-eta2; Phospholipase C-like 4; Phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Phospholipase C Eta 2 (PLCh2)
CCC D845
HGNC 29037
MGI 2443078
RGD 1304675
UniProt O75038
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol.
By EST database analysis using Pseudomonas fluorescens phosphocholine-specific phospholipase C sequence as probe, Stewart et al. (2005) identified human PLCH2. The deduced 1,442 amino acid protein contains a pleckstrin homology (PH) domain, an EF-hand domain, a predicted Ca(2+)-requiring catalytic site containing X and Y domains, and a C2 domain. PLCH2 lacks a signal peptide. In comparison to phospholipase C delta-1 (PLCD1), PLCH2 contains conserved residues known to be involved in substrate binding and catalysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD845Hu01 Recombinant Phospholipase C Eta 2 (PLCh2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD845Hu01 Polyclonal Antibody to Phospholipase C Eta 2 (PLCh2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phospholipase C Eta 2 (PLCh2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Eta 2 (PLCh2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Eta 2 (PLCh2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Eta 2 (PLCh2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Eta 2 (PLCh2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Eta 2 (PLCh2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Eta 2 (PLCh2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase C Eta 2 (PLCh2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase C Eta 2 (PLCh2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase C Eta 2 (PLCh2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase C Eta 2 (PLCh2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase C Eta 2 (PLCh2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of PLC-eta2."Biochem. J. 391:667-676(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]