Phospholipase C Zeta 1 (PLCz1)
[Edit]NYD-SP27; PLCzeta; Testis-development protein NYD-SP27; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
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PLCz1 Expressed specifically in testis. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD847Hu01 | Recombinant Phospholipase C Zeta 1 (PLCz1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD847Hu01 | Polyclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | WB; IHC; ICC; IP. |
| MAD847Hu21 | Monoclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | WB; IHC; ICC; IP. | |
| Assay Kits | SED847Hu | ELISA Kit for Phospholipase C Zeta 1 (PLCz1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phospholipase C Zeta 1 (PLCz1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phospholipase C Zeta 1 (PLCz1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phospholipase C Zeta 1 (PLCz1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phospholipase C Zeta 1 (PLCz1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phospholipase C Zeta 1 (PLCz1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phospholipase C Zeta 1 (PLCz1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phospholipase C Zeta 1 (PLCz1) | ELISA Kit Customized Service Offer |
- "Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes."Reproduction 124:611-623(2002) [PubMed] [Europe PMC] [Abstract].
- "Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C."Lancet 362:2059-2065(2003) [PubMed] [Europe PMC] [Abstract].
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes."Reproduction 128:697-702(2004) [PubMed] [Europe PMC] [Abstract]