Dynamin 3 (DNM3)

Dynamin-3 is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1998) cloned DNM3, which they designated KIAA0820. The deduced protein contains 702 amino acids. RT-PCR ELISA detected very high expression in adult brain and spinal cord and in all specific brain regions examined. Intermediate expression was detected in adult heart, lung, kidney, testis, and ovary and in fetal liver and brain. Low expression was detected in adult liver and pancreas, and little to none was detected in skeletal muscle and spleen.