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Alanine Glyoxylate Aminotransferase 2 (AGXT2)

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AGT2; Beta-Alanine-Pyruvate Aminotransferase; (R)-3-amino-2-methylpropionate--pyruvate transaminase

Alanine Glyoxylate Aminotransferase 2 (AGXT2)
CCC D855
HGNC 14412
MGI 2146052
PubMed 24586340
RGD 621767
UniProt Q9BYV1
Wiki AGXT2
AGXT2 encodes the mitochondrial alanine-glyoxylate aminotransferase, which catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.The deduced 512-amino acid rat Agxt2 enzyme has a predicted 39-amino acid precursor leader sequence and has a calculated molecular mass of 57.15 kD. Rat Agxt2 shares 29.2% identity with rat ornithine aminotransferase (OAT1) but has little similarity to rat mitochondrial Agt1 or to human peroxisomal Agt1 (AGXT).Enzyme activity assay detected alanine-glyoxylate aminotransferase and glycolate reductase activity in purified mitochondria of liver carcinoma cells, and beta-ALAAT II activity was enriched in mitochondria, suggesting that human hepatocyte mitochondria possess AGXT2 activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD855Hu01 Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD855Hu01 Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) WB; IHC; ICC; IP.
Assay Kits SED855Hu ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD855Mu01 Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD855Mu01 Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD855Ra01 Recombinant Alanine Glyoxylate Aminotransferase 2 (AGXT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD855Ra01 Polyclonal Antibody to Alanine Glyoxylate Aminotransferase 2 (AGXT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanine Glyoxylate Aminotransferase 2 (AGXT2) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production."J. Biol. Chem. 285:5385-5391(2010) [PubMed] [Europe PMC] [Abstract]
  4. "Alanine-Glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure."Arterioscler. Thromb. Vasc. Biol. 32:2892-2900(2012) [PubMed] [Europe PMC] [Abstract]
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Association of the AGXT2 V140I polymorphism with risk for coronary heart disease in a Chinese population."J. Atheroscler. Thromb. 21:1022-1030(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers."PLoS ONE 9:E88544-E88544(2014) [PubMed] [Europe PMC] [Abstract]