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Relaxin 3 (RLN3)

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ZINS4; RXN3; H3; INSL7; Insulin-like peptide 7; Prorelaxin H3

Relaxin 3 (RLN3)
CCC D869
HGNC 17135
MGI 2158015
PubMed 19416197
RGD 628745
UniProt Q8WXF3
Wiki Relaxin-3
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin.
Relaxin 3 is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Relaxin 3 (RLN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Relaxin 3 (RLN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Relaxin 3 (RLN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Relaxin 3 (RLN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Relaxin 3 (RLN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD869Mu01 Recombinant Relaxin 3 (RLN3) Positive Control; Immunogen; SDS-PAGE; WB.
RPD869Mu02 Recombinant Relaxin 3 (RLN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD869Mu01 Polyclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
PAD869Mu02 Polyclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
Assay Kits CED869Mu ELISA Kit for Relaxin 3 (RLN3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD869Ra01 Recombinant Relaxin 3 (RLN3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD869Ra01 Polyclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
MAD869Ra21 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC
MAD869Ra22 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
MAD869Ra23 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
MAD869Ra25 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
MAD869Ra27 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
MAD869Ra29 Monoclonal Antibody to Relaxin 3 (RLN3) WB; IHC; ICC; IP.
Assay Kits CED869Ra ELISA Kit for Relaxin 3 (RLN3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Production of recombinant human relaxin 3 in AtT20 cells."Regul. Pept. 113:79-84(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135."J. Biol. Chem. 278:50754-50764(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of relaxin-3/INSL7 as a ligand for GPCR142."J. Biol. Chem. 278:50765-50770(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3."J. Biol. Chem. 281:5845-5851(2006) [PubMed] [Europe PMC] [Abstract]