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Insulinoma Associated Protein 1 (INSM1)

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IA1; Zinc finger protein IA-1

Insulinoma Associated Protein 1 (INSM1)
CCC D877
HGNC 6090
MGI 1859980
PubMed 19542360
RGD 1309542
UniProt Q01101
Wiki INSM1
Insulinoma-associated protein 1 is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors
The insulinoma-associated 1 (INSM1) gene is expressed exclusively during early embryonal development, but has been found re-expressed at high levels in neuroendocrine tumors. The regulatory region of the INSM1 gene is therefore a potential candidate for regulating expression of a therapeutic gene in transcriptionally targeted cancer gene therapy against neuroendocrine tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD877Hu01 Recombinant Insulinoma Associated Protein 1 (INSM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAD877Hu22 Monoclonal Antibody to Insulinoma Associated Protein 1 (INSM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulinoma Associated Protein 1 (INSM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulinoma Associated Protein 1 (INSM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD877Mu01 Recombinant Insulinoma Associated Protein 1 (INSM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD877Mu01 Polyclonal Antibody to Insulinoma Associated Protein 1 (INSM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulinoma Associated Protein 1 (INSM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulinoma Associated Protein 1 (INSM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulinoma Associated Protein 1 (INSM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulinoma Associated Protein 1 (INSM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulinoma Associated Protein 1 (INSM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulinoma Associated Protein 1 (INSM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulinoma Associated Protein 1 (INSM1) ELISA Kit Customized Service Offer
  1. "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs."J. Biol. Chem. 267:15252-15257(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1."J. Biol. Chem. 269:14170-14174(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence."Nucleic Acids Res. 30:1038-1045(2002) [PubMed] [Europe PMC] [Abstract]
  5. "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system."J. Biol. Chem. 278:38991-38997(2003) [PubMed] [Europe PMC] [Abstract]
  6. "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]
  7. "IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas."EMBO J. 25:1344-1352(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription."J. Endocrinol. 198:29-39(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest."J. Biol. Chem. 284:5574-5581(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation."FASEB J. 23:2024-2033(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Solution NMR structure of C2H2-type zinc-fingers 4 and 5 from human insulinoma-associated protein 1 (fragment 424-497), Northeast structural genomics consortium target HR7614B (Casp target)."Submitted (OCT-2012) to the PDB data bank