Small Proline Rich Like Protein 2A (SPRL2A)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE1B, which they called LEP2. RT-PCR detected LEP2 in human skin, but not in heart or esophagus.Using real-time PCR, Jackson et al. (2005) detected low LCE1B expression in human fetal, arm, penal, and abdominal skin. Little to no expression was detected in vulva, tongue, and esophagus.

Jackson et al. (2005) determined that LCE1B is a single-exon gene.By genomic sequence analysis, Marshall et al. (2001) mapped the LCE1B gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce1b gene maps to a syntenic LCE gene cluster on chromosome 3F1.