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Small Proline Rich Like Protein 4A (SPRL4A)

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LEP8; LCE4A; Late Cornified Envelope 4A; Late envelope protein 8; Small proline-rich-like epidermal differentiation complex protein 4A

Small Proline Rich Like Protein 4A (SPRL4A)
CCC D884
HGNC 16613
UniProt Q5TA78
LCE4A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope.
By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE4A, which they called LEP8.Using real-time PCR, Jackson et al. (2005) detected very low LCE4A expression in adult and fetal skin. Little to no expression was detected in vulva, tongue, and esophagus.By genomic sequence analysis, Marshall et al. (2001) mapped the LCE4A gene to the LCE gene cluster on chromosome 1q21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD884Hu01 Recombinant Small Proline Rich Like Protein 4A (SPRL4A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Small Proline Rich Like Protein 4A (SPRL4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Like Protein 4A (SPRL4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Like Protein 4A (SPRL4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Like Protein 4A (SPRL4A) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]