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Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS)

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ALS

Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS)
CCC D892
HGNC 5468
MGI 107973
PubMed 20591980
RGD 68429
UniProt P35858
Wiki IGFALS
Until birth, binary IGFBP/IGF complexes of 50 kD predominate in serum, with IGFBP2 being the most frequently occurring IGFBP moiety. In juvenile and adult mammals, however, 80% to 85% of serum IGFs are found in a ternary complex of 150 kD composed of 1 molecule each of IGF, IGFBP3, and a protein that is found only in serum, the acid-labile subunit (ALS). ALS migrates at an apparent molecular mass of 84-86 kD. ALS cDNAs predict signal peptide and mature protein of 23 and 580 amino acids in the rat, and 27 and 578 amino acids in humans. ALS retains the IGFBP3/IGF complexes in the vascular compartment and extends the half life of IGFs in the circulation. Synthesis of ALS occurs mainly in liver after birth and is stimulated by growth hormone

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD892Hu01 Recombinant Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD892Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) WB; IHC; ICC; IP.
MAD892Hu21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) WB; IHC; ICC; IP.
Assay Kits SED892Hu ELISA Kit for Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein, Acid Labile Subunit (IGFALS) ELISA Kit Customized Service Offer
  1. "Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex."Mol. Endocrinol. 6:870-876(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes."Endocrinology 141:833-838(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum."J. Biol. Chem. 264:11843-11848(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene."N. Engl. J. Med. 350:570-577(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Total absence of functional acid labile subunit, resulting in severe insulin-like growth factor deficiency and moderate growth failure."J. Clin. Endocrinol. Metab. 91:1826-1831(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phenotypic effects of null and haploinsufficiency of acid-labile subunit in a family with two novel IGFALS gene mutations."J. Clin. Endocrinol. Metab. 92:4444-4450(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia."J. Clin. Endocrinol. Metab. 93:1616-1624(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins."Horm. Res. 71:100-110(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Acid-labile subunit deficiency and growth failure: description of two novel cases."Horm. Res. Paediatr. 73:328-334(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Acid-labile subunit (ALS) deficiency."Best Pract. Res. Clin. Endocrinol. Metab. 25:101-113(2011) [PubMed] [Europe PMC] [Abstract]