General Transcription Factor IIA, Polypeptide 2 (GTF2A2)

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A) and the general initiation factors TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH. The first step involves recognition of the TATA element by the TATA-binding subunit (TBP) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF) in TFIID.

TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 , respectively, and a 12-kD gamma subunit encoded by GTF2A2 .