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General Transcription Factor IIi (GTF2I)

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WBS; BAP135; BTKAP1; DIWS; IB291; SPIN; TFII-I; WBSCR6; Bruton tyrosine kinase-associated protein 135; Williams-Beuren syndrome chromosomal region 6 protein

General Transcription Factor IIi (GTF2I)
CCC D896
HGNC 4659
MGI 1202722
PubMed 22048961
RGD 727961
UniProt P78347
Wiki GTF2I
General transcription factor II-I is a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.
General Transcription Factor II I is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIi (GTF2I) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIi (GTF2I) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIi (GTF2I) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIi (GTF2I) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIi (GTF2I) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIi (GTF2I) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIi (GTF2I) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIi (GTF2I) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIi (GTF2I) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIi (GTF2I) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant General Transcription Factor IIi (GTF2I) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to General Transcription Factor IIi (GTF2I) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to General Transcription Factor IIi (GTF2I) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for General Transcription Factor IIi (GTF2I) CLIA Kit Customized Service Offer
n/a ELISA Kit for General Transcription Factor IIi (GTF2I) ELISA Kit Customized Service Offer
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  2. "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I."Genes Dev. 11:2482-2493(1997) [PubMed] [Europe PMC] [Abstract]
  3. "BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement."Proc. Natl. Acad. Sci. U.S.A. 94:604-609(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK."Hum. Mol. Genet. 7:325-334(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (JUL-2007) to UniProtKB
  8. "Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase."Mol. Cell. Biol. 19:5014-5024(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I."J. Biol. Chem. 276:27806-27815(2001) [PubMed] [Europe PMC] [Abstract]
  10. "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I."J. Biol. Chem. 277:32003-32014(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."Mol. Cell. Biol. 26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Solution structure of RSGI RUH-052, a GTF2I domain in human."Submitted (AUG-2007) to the PDB data bank