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Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3)

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SMD3; SNRP-D3; snRNP core protein D3

Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3)
CCC D914
HGNC 11160
MGI 1914582
PubMed 23236152
UniProt P62318
Wiki SNRPD3
Lehmeier et al. (1994) obtained partial amino acid sequence for the D2 and D3 protein components of small nuclear ribonucleoproteins (snRNPs). Degenerate oligomers were designed and used to isolate 2 cDNAs from a HeLa cell library. The sequence of the D3 cDNA predicts a 126-amino acid protein with 29% identity to the D1 polypeptide. Recombinantly expressed protein could be precipitated with anti-Sm antibodies.
Small nuclear ribonucleoprotein Sm D3 is a protein that belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. SNRPD3 has been shown to interact with DDX20, CLNS1A, CDC5L and Protein arginine methyltransferase 5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD914Hu01 Recombinant Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD914Hu01 Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein Polypeptide D3 (SNRPD3) ELISA Kit Customized Service Offer
  1. "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction."Proc. Natl. Acad. Sci. U.S.A. 91:12317-12321(1994) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln."Curr. Biol. 11:1990-1994(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins."J. Cell Biol. 178:733-740(2007) [PubMed] [Europe PMC] [Abstract]
  12. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]