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Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)

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CD358; BM-018; DR6; Death Receptor 6

Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)
CCC D929
HGNC 13469
MGI 2151075
PubMed 21738152
RGD 1307308
UniProt O75509
Wiki TNFRSF21
Tumor necrosis factor receptor superfamily, member 21 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T helper cell activation, and may be involved in inflammation and immune regulation.Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD929Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD929Hu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) WB; IHC
LAD929Hu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD929Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD929Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) WB; IHC; ICC; IP.
LAD929Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) ELISA Kit Customized Service Offer
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  9. "A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death."Cell Death Dis. 4:E579-E579(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the carboxyl-terminal CARD-like domain in human TNFR-related death receptor-6."Submitted (DEC-2006) to the PDB data bank
  11. "The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP)."J. Mol. Biol. 409:189-201(2011) [PubMed] [Europe PMC] [Abstract]
  12. "S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS."Acta Crystallogr. D 68:521-530(2012) [PubMed] [Europe PMC] [Abstract]