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5',3'-Nucleotidase, Cytosolic (NT5C)

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DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; 5'Nucleotidase,Deoxy(Pyrimidine)Cytosolic Type C; Uridine 5-Prime Monophosphate Hydrolase 2; 5'(3')-deoxyribonucleotidase, cytosolic

5',3'-Nucleotidase, Cytosolic (NT5C)
CCC D938
HGNC 17144
MGI 1354954
PubMed 21873433
UniProt Q8TCD5
Wiki NT5C

Pyrimidine 5-prime nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1) and type II (UMPH2). Detected in skeletal muscle, heart and pancreas.

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD938Hu01 Recombinant 5',3'-Nucleotidase, Cytosolic (NT5C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD938Hu01 Polyclonal Antibody to 5',3'-Nucleotidase, Cytosolic (NT5C) WB; IHC; ICC; IP.
Assay Kits SED938Hu ELISA Kit for 5',3'-Nucleotidase, Cytosolic (NT5C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD938Mu01 Recombinant 5',3'-Nucleotidase, Cytosolic (NT5C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD938Mu01 Polyclonal Antibody to 5',3'-Nucleotidase, Cytosolic (NT5C) WB; IHC; ICC; IP.
Assay Kits SED938Mu ELISA Kit for 5',3'-Nucleotidase, Cytosolic (NT5C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5',3'-Nucleotidase, Cytosolic (NT5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5',3'-Nucleotidase, Cytosolic (NT5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5',3'-Nucleotidase, Cytosolic (NT5C) Polyclonal Antibody Customized Service Offer
Assay Kits SED938Ra ELISA Kit for 5',3'-Nucleotidase, Cytosolic (NT5C) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells."J. Biol. Chem. 275:5409-5415(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs."Gene 294:109-117(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues."Biochemistry 46:13809-13818(2007) [PubMed] [Europe PMC] [Abstract]