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Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1)

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THRA1; EAR1; THRAL; ear-1; hRev; Rev-ErbA Alpha; V-erbA-related protein 1

Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1)
CCC D945
HGNC 7962
MGI 2444210
PubMed 19926613
RGD 628827
UniProt P20393
Rev-erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues.
Rev-erbα is transcribed from the opposite strand of the thyroid receptor α (c-erbAα) gene on chromosome 17, with a 269-nucleotide overlap between the two transcripts. The other mammalian isoform of the receptor, Rev-erbβ is encoded by another gene on chromosome 3. In addition, there is one non-mammalian homolog, the ecdysone-regulated gene E75, which is present in Drosophila and C. elegans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD945Hu01 Recombinant Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD945Hu01 Polyclonal Antibody to Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) WB; IHC; ICC; IP.
Assay Kits SED945Hu ELISA Kit for Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) ELISA Kit Customized Service Offer
  1. "Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus."Cell 57:31-39(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone."DNA Cell Biol. 9:77-83(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene."Nucleic Acids Res. 19:1105-1112(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Orphan nuclear hormone receptor Rev-erbalpha regulates the human apolipoprotein CIII promoter."J. Biol. Chem. 277:27120-27129(2002) [PubMed] [Europe PMC] [Abstract]
  6. "The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene."Mol. Endocrinol. 19:1452-1459(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1."J. Biol. Chem. 281:33842-33848(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock."Science 311:1002-1005(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription."FEBS J. 274:5370-5381(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways."Science 318:1786-1789(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha."Genes Dev. 23:2201-2209(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism."Nucl. Recept. Signal. 8:E001-E001(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."Nat. Neurosci. 14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Direct regulation of CLOCK expression by REV-ERB."PLoS ONE 6:E17290-E17290(2011) [PubMed] [Europe PMC] [Abstract]
  16. "REV-ERBs: more than the sum of the individual parts."Cell Metab. 15:791-793(2012) [PubMed] [Europe PMC] [Abstract]
  17. "REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology."Cell Res. 22:1319-1321(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines."Proc. Natl. Acad. Sci. U.S.A. 109:582-587(2012) [PubMed] [Europe PMC] [Abstract]
  19. "DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha."Biochem. J. 451:453-461(2013) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structural elements of an orphan nuclear receptor-DNA complex."Mol. Cell 1:849-861(1998) [PubMed] [Europe PMC] [Abstract]