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RAR Related Orphan Receptor Alpha (RORa)

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ROR1; ROR2; NR1F1; ROR3; RZRA; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha

RAR Related Orphan Receptor Alpha (RORa)
CCC D947
HGNC 10258
MGI 104661
PubMed 21359227
UniProt P35398
Wiki RORA
ROR-alpha), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor encoded by the RORA gene.
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD947Hu01 Recombinant RAR Related Orphan Receptor Alpha (RORa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD947Hu01 Polyclonal Antibody to RAR Related Orphan Receptor Alpha (RORa) WB
Assay Kits SED947Hu ELISA Kit for RAR Related Orphan Receptor Alpha (RORa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAR Related Orphan Receptor Alpha (RORa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAR Related Orphan Receptor Alpha (RORa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAR Related Orphan Receptor Alpha (RORa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAR Related Orphan Receptor Alpha (RORa) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAR Related Orphan Receptor Alpha (RORa) ELISA Kit Customized Service Offer
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  12. "Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1."J. Biol. Chem. 279:15025-15031(2004) [PubMed] [Europe PMC] [Abstract]
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  14. "Identification of the human ApoAV gene as a novel RORalpha target gene."Biochem. Biophys. Res. Commun. 330:233-241(2005) [PubMed] [Europe PMC] [Abstract]
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  16. "Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro."Biochem. Biophys. Res. Commun. 358:890-896(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
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  19. "Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C."J. Neurochem. 104:1321-1332(2008) [PubMed] [Europe PMC] [Abstract]
  20. "SUMOylation of RORalpha potentiates transcriptional activation function."Biochem. Biophys. Res. Commun. 378:513-517(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)."J. Biol. Rhythms 26:187-199(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."Nature 472:491-494(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
  26. "EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex."Mol. Cell 48:572-586(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Action of RORs and their ligands in (patho)physiology."Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
  28. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  29. "X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha."Structure 10:1697-1707(2002) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A."J. Biol. Chem. 279:14033-14038(2004) [PubMed] [Europe PMC] [Abstract]