RAR Related Orphan Receptor Gamma (RORg)
[Edit]RORC; NR1F3; RORG; RZRG; TOR; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma
RORγ is expressed in many tissues, including thymus, lung, liver, kidney, muscle, and brown fat. While RORγ mRNA is abundantly expressed, attempts to detect RORγ protein have not been successful therefore it is not clear whether RORγ protein is actually expressed. Consistent with this, the main phenotypes identified in RORγ knockout mice (where neither isoform is expressed) are those associated with RORγt immune system function and an isoform specific RORγt knockout displayed a phenotype identical to the RORγ knockout. On the other hand, circadian phenotypes of RORγ mice in tissues where the RORγt isoform is expressed in minute amounts argues for the expression of functional RORγ isoform. Absent protein in previous studies may be due to the high amplitude circadian rhythm of expression of this isoform in some tissues.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD949Hu01 | Recombinant RAR Related Orphan Receptor Gamma (RORg) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD949Hu01 | Polyclonal Antibody to RAR Related Orphan Receptor Gamma (RORg) | WB; IHC; ICC; IP. |
MAD949Hu21 | Monoclonal Antibody to RAR Related Orphan Receptor Gamma (RORg) | WB; IHC; ICC; IP. | |
Assay Kits | SED949Hu | ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD949Mu01 | Recombinant RAR Related Orphan Receptor Gamma (RORg) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD949Mu01 | Polyclonal Antibody to RAR Related Orphan Receptor Gamma (RORg) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for RAR Related Orphan Receptor Gamma (RORg) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD949Ra01 | Recombinant RAR Related Orphan Receptor Gamma (RORg) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD949Ra01 | Polyclonal Antibody to RAR Related Orphan Receptor Gamma (RORg) | WB; IHC; ICC; IP. |
MAD949Ra21 | Monoclonal Antibody to RAR Related Orphan Receptor Gamma (RORg) | WB; IHC; ICC; IP. | |
Assay Kits | SED949Ra | ELISA Kit for RAR Related Orphan Receptor Gamma (RORg) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle."Biochem. Biophys. Res. Commun. 205:1976-1983(1994) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function."Nature 453:236-240(2008) [PubMed] [Europe PMC] [Abstract]
- "Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]
- "A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)."Biochim. Biophys. Acta 1801:917-923(2010) [PubMed] [Europe PMC] [Abstract]
- "Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]
- "Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."EMBO Mol. Med. 3:637-651(2011) [PubMed] [Europe PMC] [Abstract]
- "Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."Nature 472:491-494(2011) [PubMed] [Europe PMC] [Abstract]
- "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
- "Action of RORs and their ligands in (patho)physiology."Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma."Mol. Endocrinol. 24:923-929(2010) [PubMed] [Europe PMC] [Abstract]