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Liver Receptor Homolog 1 (LRH1)

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NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; LRH-1; hB1F; hB1F-2; Hepatocytic transcription factor; Alpha-1-fetoprotein transcription factor; Nuclear Receptor Subfamily 5,Group A,Member 2

Liver Receptor Homolog 1 (LRH1)
CCC D965
HGNC 7984
MGI 1346834
RGD 68353
UniProt O00482
By means of yeast 1-hybrid screening of a liver cDNA library, Li et al. (1998) cloned a cDNA encoding a novel hepatocyte transcription factor, which they called HB1F for human B1-binding factor. The deduced 495-amino acid protein, which has a molecular mass of 54 kD, belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors and is closely related to steroidogenic factor-1 (SF1), another member of this subfamily.
HB1F contains a DNA-binding domain with 2 zinc finger motifs, an FTZ-F1 box, and a ligand-binding domain. Northern blot analysis revealed that HB1F is expressed in liver, pancreas, and lung as a 5.2-kb transcript. An additional transcript of 3.8 kb was present in hepatoma cells HepG2. The authors identified 2 HB1F isoforms which differ in their A/B region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD965Hu01 Recombinant Liver Receptor Homolog 1 (LRH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD965Hu01 Polyclonal Antibody to Liver Receptor Homolog 1 (LRH1) WB; IHC; ICC; IP.
MAD965Hu21 Monoclonal Antibody to Liver Receptor Homolog 1 (LRH1) WB; IHC; ICC; IP.
Assay Kits SED965Hu ELISA Kit for Liver Receptor Homolog 1 (LRH1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Liver Receptor Homolog 1 (LRH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Liver Receptor Homolog 1 (LRH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Liver Receptor Homolog 1 (LRH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Liver Receptor Homolog 1 (LRH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Liver Receptor Homolog 1 (LRH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD965Ra01 Recombinant Liver Receptor Homolog 1 (LRH1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD965Ra01 Polyclonal Antibody to Liver Receptor Homolog 1 (LRH1) WB; IHC; ICC; IP.
MAD965Ra21 Monoclonal Antibody to Liver Receptor Homolog 1 (LRH1) WB; IHC; ICC; IP.
Assay Kits SED965Ra ELISA Kit for Liver Receptor Homolog 1 (LRH1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus."J. Biol. Chem. 273:29022-29031(1998) [PubMed] [Europe PMC] [Abstract]
  2. "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene."Proc. Natl. Acad. Sci. U.S.A. 96:6660-6665(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene."Gene 273:239-249(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization."Cytogenet. Cell Genet. 82:269-270(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1."Cell 120:343-355(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity."J. Mol. Biol. 354:1091-1102(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP."Nat. Struct. Mol. Biol. 12:357-363(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1."Proc. Natl. Acad. Sci. U.S.A. 102:7505-7510(2005) [PubMed] [Europe PMC] [Abstract]