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Adrenergic Receptor Beta 3 (ADRb3)

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BETA3AR; B3AR; Beta-3 adrenoreceptor

Adrenergic Receptor Beta 3 (ADRb3)
CCC D979
HGNC 288
MGI 87939
PubMed 22391136
RGD 2061
UniProt P13945
Wiki ADRb3
ADRb3 is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some β3 agonists have demonstrated antistress effects in animal studies, suggesting it also has a role in the CNS. Beta3-Receptors are found in the gallbladder and in brain adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat.
Beta adrenergic receptors are involved in the epinephrine- and norepinephrine-induced activation of adenylate cyclase through ngono the action of the G proteins of the type Gs.SR 59230A was thought to be a selective β3 antagonist but later found to also be an antagonist of the α1 receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adrenergic Receptor Beta 3 (ADRb3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) Polyclonal Antibody Customized Service Offer
Assay Kits SED979Hu ELISA Kit for Adrenergic Receptor Beta 3 (ADRb3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD979Mu01 Recombinant Adrenergic Receptor Beta 3 (ADRb3) Positive Control; Immunogen; SDS-PAGE; WB.
RPD979Mu02 Recombinant Adrenergic Receptor Beta 3 (ADRb3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD979Mu01 Polyclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) WB; IHC; ICC; IP.
PAD979Mu02 Polyclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) WB; IHC; ICC; IP.
Assay Kits SED979Mu ELISA Kit for Adrenergic Receptor Beta 3 (ADRb3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD979Ra01 Recombinant Adrenergic Receptor Beta 3 (ADRb3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD979Ra01 Polyclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) WB; IHC; ICC; IP.
MAD979Ra21 Monoclonal Antibody to Adrenergic Receptor Beta 3 (ADRb3) WB; IHC; ICC; IP.
Assay Kits SED979Ra ELISA Kit for Adrenergic Receptor Beta 3 (ADRb3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular characterization of the human beta 3-adrenergic receptor."Science 245:1118-1121(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes."Eur. J. Biochem. 213:1117-1124(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a human beta 3-adrenergic receptor cDNA."FEBS Lett. 324:127-130(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block."Mol. Pharmacol. 42:964-970(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity."N. Engl. J. Med. 333:352-354(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain."Diabetologia 39:349-352(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant."Endocrinology 137:2638-2641(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]