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Calcyon Neuron Specific Vesicular Protein (CALY)

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DRD1IP; CALCYON; NSG3; Dopamine Receptor D1 Interacting Protein

Calcyon Neuron Specific Vesicular Protein (CALY)
CCC D980
HGNC 17938
MGI 1915816
PubMed 17885599
RGD 621719
UniProt Q9NYX4
Wiki Calcyon
CALCYON is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. Lezcano et al.identified a cDNA from human brain which they designated calcyon, for 'calcium on,' which encodes a 217-amino acid type II single transmembrane protein. Calcyon has a high degree of sequence similarity to the neuronal proteins p19 and p21. Immunoblot and immunolocalization analyses revealed expression of a 34-kD glycosylated protein in pyramidal neuron dendritic spines in prefrontal cortex and suggested an orientation with extracellular N terminus and cytoplasmic C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD980Hu01 Recombinant Calcyon Neuron Specific Vesicular Protein (CALY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD980Hu01 Polyclonal Antibody to Calcyon Neuron Specific Vesicular Protein (CALY) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD980Mu01 Recombinant Calcyon Neuron Specific Vesicular Protein (CALY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD980Mu01 Polyclonal Antibody to Calcyon Neuron Specific Vesicular Protein (CALY) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD980Ra01 Recombinant Calcyon Neuron Specific Vesicular Protein (CALY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD980Ra01 Polyclonal Antibody to Calcyon Neuron Specific Vesicular Protein (CALY) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcyon Neuron Specific Vesicular Protein (CALY) ELISA Kit Customized Service Offer
  1. "Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein."Science 287:1660-1664(2000) [PubMed] [Europe PMC] [Abstract]
  2. ErratumScience 314:1681-1681(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia."Arch. Gen. Psychiatry 60:311-319(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane."J. Biol. Chem. 278:51654-51663(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis."J. Biol. Chem. 281:15182-15193(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  9. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]