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Protein Arginine Methyltransferase 3 (PRMT3)

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HRMT1L3; HMT1 hnRNP Methyltransferase-Like 3; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

Protein Arginine Methyltransferase 3 (PRMT3)
CCC D989
HGNC 30163
MGI 1919224
PubMed 21059412
RGD 620413
UniProt O60678
Wiki PRMT3
Type I protein arginine N-methyltransferases (PRMTs), such as PRMT3, catalyze the formation of asymmetric N(G),N(G)-dimethylarginine (ADMA) residues in prote.The C-terminal region of the deduced protein, which contains the putative methyltransferase domain, is 46% identical to Prmt1. The N-terminal 194-amino acid portion is rich in acidic residues and contains a putative zinc finger motif. Immunofluorescence experiments localized Prmt3 predominantly to the cytoplasm of mammalian cells. By searching an EST database, Tang et al. (1998) identified a partial cDNA encoding the human homolog of Prmt3. The predicted human PRMT3 protein, which is missing the first 16 N-terminal amino acids, is 90% identical to rat Prmt3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Arginine Methyltransferase 3 (PRMT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Arginine Methyltransferase 3 (PRMT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Arginine Methyltransferase 3 (PRMT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Arginine Methyltransferase 3 (PRMT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Arginine Methyltransferase 3 (PRMT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Arginine Methyltransferase 3 (PRMT3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Arginine Methyltransferase 3 (PRMT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Arginine Methyltransferase 3 (PRMT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Arginine Methyltransferase 3 (PRMT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Arginine Methyltransferase 3 (PRMT3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation."J. Biol. Chem. 273:16935-16945(1998) [PubMed] [Europe PMC] [Abstract]
  5. "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo."Oncogene 23:7761-7771(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3)."Biochim. Biophys. Acta 1814:277-282(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "The crystal structure of human HMT1 HNRNP methyltransferase-like 3 in complex with SAH."Submitted (MAR-2006) to the PDB data bank