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Cathepsin G (CTSG)

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CG; CTS-G

Cathepsin G (CTSG)
CCC D993
HGNC 2532
MGI 88563
PubMed 7341917
RGD 1307681
UniProt P08311
Wiki Cathepsin_G
Neutrophilic polymorphonuclear leukocytes contain specialized azurophil granules whose contents, including the serine proteases cathepsin G and elastase, may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Cathepsin G is a 26,000-Da protease.
Cathepsin G isa member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD993Hu01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD993Hu01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
MAD993Hu21 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
Assay Kits SED993Hu ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD993Mu01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
RPD993Mu02 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD993Mu01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAD993Mu02 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
LAD993Mu71 Biotin-Linked Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC.
LAD993Mu81 FITC-Linked Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits SED993Mu ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection.
HED993Mu High Sensitive ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD993Ra01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
APD993Ra01 Active Cathepsin G (CTSG) Cell culture; Activity Assays.
Antibodies PAD993Ra01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
MAD993Ra21 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
Assay Kits SED993Ra ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases."Biochemistry 26:2289-2293(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and chromosomal localization of the human cathepsin G gene."J. Biol. Chem. 264:13412-13419(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G."FEBS Lett. 345:81-86(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors."Anal. Biochem. 158:217-227(1986) [PubMed] [Europe PMC] [Abstract]
  6. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G."J. Immunol. 147:921-926(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis."J. Immunol. Methods 180:25-33(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa."Infect. Immun. 59:4193-4200(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities."EMBO J. 15:5481-5491(1996) [PubMed] [Europe PMC] [Abstract]
  12. , Submitted (SEP-1997) to the PDB data bank
  13. "Sequence variant of the human cathepsin G gene."Hum. Genet. 91:83-84(1993) [PubMed] [Europe PMC] [Abstract]