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Procollagen C Proteinase Enhancer 2 (PCPE2)

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PCOLCE2; Procollagen C Endopeptidase Enhancer 2; Procollagen COOH-terminal proteinase enhancer 2

Procollagen C Proteinase Enhancer 2 (PCPE2)
CCC D996
HGNC 8739
MGI 1923727
PubMed 12393877
UniProt Q9UKZ9
Wiki PCOLCE2
PCOLCE2 lies 5.2 kb and 102.5 kb centromeric to the transient receptor potential channel-1 (TRPC1) and plastin-1 (PLS1), respectively. The deduced 415-amino acid protein contains an N-terminal signal sequence, 2 CUB domains, and an NTR domain. It also contains a putative myristoylation site, several potential phosphorylation sites, a putative glycosylation site, and an RGD site. PCOLCE2 shares about 43% sequence identity with the PCOLCE protein .
The secreted PCOLCE2 protein is calculated to have a molecular mass of about 47 kD. Northern blot analysis detected ubiquitous expression of a 2-kb transcript, with highest expression in heart, placenta, and trabecular meshwork, and very low expression in brain. Western blot analysis revealed a 52-kD form of PCOLCE2 in human fibroblast cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD996Hu01 Recombinant Procollagen C Proteinase Enhancer 2 (PCPE2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD996Hu02 Recombinant Procollagen C Proteinase Enhancer 2 (PCPE2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD996Hu01 Polyclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) WB; IHC; ICC; IP.
PAD996Hu02 Polyclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) WB; IHC; ICC; IP.
LAD996Hu71 Biotin-Linked Polyclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) WB; IHC; ICC.
MAD996Hu21 Monoclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Procollagen C Proteinase Enhancer 2 (PCPE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Procollagen C Proteinase Enhancer 2 (PCPE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Procollagen C Proteinase Enhancer 2 (PCPE2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Procollagen C Proteinase Enhancer 2 (PCPE2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Procollagen C Proteinase Enhancer 2 (PCPE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Procollagen C Proteinase Enhancer 2 (PCPE2) ELISA Kit Customized Service Offer
  1. "Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24."Genomics 66:264-273(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries."Osteoarthritis Cartilage 9:641-653(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1."J. Biol. Chem. 277:49820-49830(2002) [PubMed] [Europe PMC] [Abstract]