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Cyclic AMP Response Element Binding Protein 3 (CREB3)

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LUMAN; LZIP; cAMP-responsive element-binding protein 3; Leucine zipper protein; Luman; Transcription factor LZIP-alpha; Transcriptionally active form

Cyclic AMP Response Element Binding Protein 3 (CREB3)
CCC D997
HGNC 2347
MGI 99946
PubMed 24185178
RGD 1308831
UniProt O43889
Wiki CREB3
Cyclic AMP-responsive element-binding protein 3 is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes.
This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Binding Protein 3 (CREB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Polyclonal Antibody Customized Service Offer
Assay Kits SED997Hu ELISA Kit for Cyclic AMP Response Element Binding Protein 3 (CREB3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Binding Protein 3 (CREB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Binding Protein 3 (CREB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Binding Protein 3 (CREB3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Binding Protein 3 (CREB3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Binding Protein 3 (CREB3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Binding Protein 3 (CREB3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Binding Protein 3 (CREB3) ELISA Kit Customized Service Offer
  1. "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor."Mol. Cell. Biol. 17:5117-5126(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP."Genes Dev. 11:3122-3127(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation."EMBO J. 19:729-740(2000) [PubMed] [Europe PMC] [Abstract]
  4. "A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor."Mol. Endocrinol. 23:1746-1757(2009) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency."J. Virol. 74:934-943(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP."Mol. Cell. Biol. 20:919-928(2000) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif."Proc. Natl. Acad. Sci. U.S.A. 97:10757-10762(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis."Mol. Cell. Biol. 22:5639-5649(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines."FASEB J. 18:890-892(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Luman is capable of binding and activating transcription from the unfolded protein response element."Biochem. Biophys. Res. Commun. 331:113-119(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman."J. Biol. Chem. 280:15257-15266(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR."J. Mol. Biol. 364:1034-1047(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."Mol. Cell. Biol. 26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1."J. Biol. Chem. 282:11092-11100(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response."Mol. Cell. Biol. 28:3952-3966(2008) [PubMed] [Europe PMC] [Abstract]
  19. "DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation."Mol. Immunol. 47:1963-1973(2010) [PubMed] [Europe PMC] [Abstract]