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CREB Binding Protein (CREBBP)

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CBP; RSTS; RTS; KAT3A; Rubinstein-Taybi Syndrome

CREB Binding Protein (CREBBP)
CCC E002
HGNC 2348
MGI 1098280
PubMed 21390130
RGD 2401
UniProt Q92793
Wiki CREBBP
CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high-sequence similarity with protein EP300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE002Hu01 Recombinant CREB Binding Protein (CREBBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE002Hu01 Polyclonal Antibody to CREB Binding Protein (CREBBP) WB; IHC; ICC; IP.
MAE002Hu21 Monoclonal Antibody to CREB Binding Protein (CREBBP) WB; IHC; ICC; IP.
Assay Kits SEE002Hu ELISA Kit for CREB Binding Protein (CREBBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE002Mu01 Recombinant CREB Binding Protein (CREBBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE002Mu01 Polyclonal Antibody to CREB Binding Protein (CREBBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for CREB Binding Protein (CREBBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for CREB Binding Protein (CREBBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE002Ra01 Recombinant CREB Binding Protein (CREBBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE002Ra01 Polyclonal Antibody to CREB Binding Protein (CREBBP) WB; IHC; ICC; IP.
Assay Kits SEE002Ra ELISA Kit for CREB Binding Protein (CREBBP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)."Proc. Natl. Acad. Sci. U.S.A. 94:8732-8737(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3."Genomics 42:96-114(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein."Nat. Genet. 14:33-41(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)."Hum. Mol. Genet. 10:395-404(2001) [PubMed] [Europe PMC] [Abstract]
  5. "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A."Nature 382:319-324(1996) [PubMed] [Europe PMC] [Abstract]
  6. "An essential role for p300/CBP in the cellular response to hypoxia."Proc. Natl. Acad. Sci. U.S.A. 93:12969-12973(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300."Mol. Cell. Biol. 18:2392-2405(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases."Proc. Natl. Acad. Sci. U.S.A. 95:9855-9860(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein."J. Biol. Chem. 274:16370-16376(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling."Proc. Natl. Acad. Sci. U.S.A. 96:2627-2632(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase."Cell 98:675-686(1999) [PubMed] [Europe PMC] [Abstract]
  12. "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors."J. Biol. Chem. 275:8825-8834(2000) [PubMed] [Europe PMC] [Abstract]
  13. "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."Mol. Cell. Biol. 20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation."J. Biol. Chem. 276:10715-10721(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Requirement of two NFATc4 transactivation domains for CBP potentiation."J. Biol. Chem. 276:39569-39576(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
  17. "The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation."Mol. Cell. Biol. 21:5520-5530(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300."J. Virol. 75:9885-9895(2001) [PubMed] [Europe PMC] [Abstract]
  19. "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression."J. Biol. Chem. 276:33881-33892(2001) [PubMed] [Europe PMC] [Abstract]
  20. "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha."J. Biol. Chem. 276:38272-38279(2001) [PubMed] [Europe PMC] [Abstract]
  21. "HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators."Oncogene 20:800-811(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb."Cell Growth Differ. 13:69-75(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."J. Biol. Chem. 277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase."Mol. Cell. Biol. 22:3549-3561(2002) [PubMed] [Europe PMC] [Abstract]
  25. "Interferon regulatory factor-2 regulates cell growth through its acetylation."J. Biol. Chem. 278:25401-25407(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination."J. Biol. Chem. 278:26102-26110(2003) [PubMed] [Europe PMC] [Abstract]
  27. "P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain."J. Bone Miner. Res. 18:1419-1429(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86."J. Biol. Chem. 279:25241-25250(2004) [PubMed] [Europe PMC] [Abstract]
  30. "FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)."J. Biol. Chem. 279:28873-28879(2004) [PubMed] [Europe PMC] [Abstract]
  31. "The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies."Neurosci. Lett. 370:191-195(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."Proc. Natl. Acad. Sci. U.S.A. 101:10042-10047(2004) [PubMed] [Europe PMC] [Abstract]
  33. "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator."Science 303:197-202(2004) [PubMed] [Europe PMC] [Abstract]
  34. "Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB."Mol. Cell 26:75-87(2007) [PubMed] [Europe PMC] [Abstract]
  35. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."Cancer Res. 68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]
  37. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  40. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  42. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  43. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  44. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  45. "CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis."Nucleic Acids Res. 42:8433-8448(2014) [PubMed] [Europe PMC] [Abstract]
  46. "Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response."Proc. Natl. Acad. Sci. U.S.A. 99:5271-5276(2002) [PubMed] [Europe PMC] [Abstract]
  47. "Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein."EMBO J. 20:7184-7196(2001) [PubMed] [Europe PMC] [Abstract]
  48. "NMR mapping of the HIV-1 Tat interaction surface of the KIX domain of the human coactivator CBP."Biochemistry 43:904-908(2004) [PubMed] [Europe PMC] [Abstract]
  49. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]
  50. "Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation."Proc. Natl. Acad. Sci. U.S.A. 111:E1072-E1081(2014) [PubMed] [Europe PMC] [Abstract]
  51. "Structural insights into acetylated-histone H4 recognition by the bromodomain-PHD finger module of human transcriptional coactivator CBP."Structure 22:353-360(2014) [PubMed] [Europe PMC] [Abstract]
  52. "Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome."Hum. Mol. Genet. 10:1071-1076(2001) [PubMed] [Europe PMC] [Abstract]
  53. "Molecular studies in 10 cases of Rubinstein-Taybi syndrome, including a mild variant showing a missense mutation in codon 1175 of CREBBP."J. Med. Genet. 39:496-501(2002) [PubMed] [Europe PMC] [Abstract]
  54. "Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome."Hum. Mol. Genet. 12:441-450(2003) [PubMed] [Europe PMC] [Abstract]
  55. "Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease."Am. J. Hum. Genet. 76:572-580(2005) [PubMed] [Europe PMC] [Abstract]
  56. "Inheritance and variable expression in Rubinstein-Taybi syndrome."Am. J. Med. Genet. A 152A:2254-2261(2010) [PubMed] [Europe PMC] [Abstract]
  57. "Insights into genotype-phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein-Taybi syndrome patients."Clin. Genet. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]