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Cyclic AMP Response Element Modulator (CREM)

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ICER; hCREM-2; Inducible cAMP early repressor

Cyclic AMP Response Element Modulator (CREM)
CCC E003
HGNC 2352
MGI 88495
PubMed 12626549
RGD 2402
UniProt Q03060
Wiki CREM
cAMP-responsive element modulator is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes.
Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE003Hu01 Recombinant Cyclic AMP Response Element Modulator (CREM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Modulator (CREM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Modulator (CREM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Modulator (CREM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Modulator (CREM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Modulator (CREM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclic AMP Response Element Modulator (CREM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclic AMP Response Element Modulator (CREM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclic AMP Response Element Modulator (CREM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclic AMP Response Element Modulator (CREM) ELISA Kit Customized Service Offer
  1. "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA."J. Biochem. 115:298-303(1994) [PubMed] [Europe PMC] [Abstract]
  2. "cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes."Proc. Natl. Acad. Sci. U.S.A. 93:3536-3541(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates."Mol. Hum. Reprod. 8:965-976(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript."Cell Growth Differ. 4:931-937(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes."Nucleic Acids Res. 20:6106-6106(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?"Mol. Hum. Reprod. 11:567-574(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis."Mol. Cell. Biol. 19:5001-5013(1999) [PubMed] [Europe PMC] [Abstract]
  11. "CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis."Mol. Hum. Reprod. 6:967-972(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis."Theriogenology 60:1357-1369(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]