≡

Calcium Binding Protein 1 (CABP1)

[Edit]

Caldendrin; Calbrain

Calcium Binding Protein 1 (CABP1)
CCC E005
HGNC 1384
MGI 1352750
PubMed 23650371
RGD 620385
UniProt Q9NZU7
Wiki CABP1
Calcium-binding protein 1, also known as caldendrin and calbrain, is a calcium-binding protein discovered in 1999. It has two EF hand motifs and is expressed in neuronal cells in such areas as hippocampus, habenular nucleus of the epithalamus, Purkinje cell layer of the cerebellum, and the amacrine cells and cone bipolar cells of the retina.
Cellular expression of caldendrin is restricted to the somato–dendritic compartment, with the exception of hypothalamus, where axonal labeling was detected.In schizophrenia, one study demonstrated a decrease in the number of CABP1-expressing cells, specifically in the left dorsolateral prefrontal cortex. This change, however, was compensated on a whole-brain scale by an increase in the protein levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE005Hu01 Recombinant Calcium Binding Protein 1 (CABP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE005Hu01 Polyclonal Antibody to Calcium Binding Protein 1 (CABP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Binding Protein 1 (CABP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein 1 (CABP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Binding Protein 1 (CABP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Binding Protein 1 (CABP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Binding Protein 1 (CABP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Binding Protein 1 (CABP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein 1 (CABP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Binding Protein 1 (CABP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Binding Protein 1 (CABP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Binding Protein 1 (CABP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Binding Protein 1 (CABP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein 1 (CABP1) ELISA Kit Customized Service Offer
  1. "Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain."J. Biol. Chem. 274:3610-3616(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin."J. Biol. Chem. 275:1247-1260(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment."J. Biol. Chem. 273:21324-21331(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1."Nat. Neurosci. 5:210-217(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins."EMBO J. 23:312-321(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling."J. Biol. Chem. 279:547-555(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."J. Mol. Biol. 336:957-970(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels."J. Neurosci. 24:4698-4708(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular mechanism for divergent regulation of Cav1.2 Ca2+ channels by calmodulin and Ca2+-binding protein-1."J. Biol. Chem. 280:29612-29619(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes."Pflugers Arch. 450:345-354(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels."J. Biol. Chem. 280:37461-37470(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1."J. Biol. Chem. 284:2472-2481(2009) [PubMed] [Europe PMC] [Abstract]