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Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B)

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DARPP-32; Dopamine And cAMP Regulated Phosphoprotein; Dopamine and cAMP-regulated neuronal phosphoprotein

Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B)
CCC E017
HGNC 9287
MGI 94860
PubMed 22559203
RGD 621859
UniProt Q9UD71
Wiki PPP1R1B
Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders.In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE017Hu01 Recombinant Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE017Hu21 Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) WB; IHC; ICC; IP.
PAE017Hu01 Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) WB; IHC; ICC; IP.
Assay Kits SEE017Hu ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1, Regulatory Subunit 1B (PPP1R1B) ELISA Kit Customized Service Offer
  1. "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue."J. Neurosci. 14:985-998(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP."Cancer Res. 62:4061-4064(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons."Nature 402:669-671(1999) [PubMed] [Europe PMC] [Abstract]