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Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a)

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PR65A; Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform; Medium tumor antigen-associated 61 kDa protein

Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a)
CCC E022
HGNC 9302
MGI 1926334
PubMed 20826764
RGD 620907
UniProt P30153
Wiki PPP2R1A
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division.
It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Alpha (PPP2R1a) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein."Proc. Natl. Acad. Sci. U.S.A. 86:8669-8672(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure."Biochemistry 29:3166-3173(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (MAR-2007) to UniProtKB
  5. "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits."Biochem. J. 317:187-194(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens."J. Virol. 68:123-129(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction between protein phosphatase 2A and members of the importin beta superfamily."Biochem. Biophys. Res. Commun. 303:908-913(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation."Dev. Cell 10:575-585(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55."EMBO J. 26:402-411(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells."J. Cell Sci. 120:1393-1404(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs."Cell 96:99-110(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Structural mechanism of demethylation and inactivation of protein phosphatase 2A."Cell 133:154-163(2008) [PubMed] [Europe PMC] [Abstract]