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Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b)

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PR65B; PP2A-A-beta; Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta Isoform

Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b)
CCC E023
HGNC 9303
MGI 1920949
PubMed 23267135
RGD 1304764
UniProt P30154
Wiki PPP2R1A
PPP2R1B encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit A Beta (PPP2R1b) ELISA Kit Customized Service Offer
  1. "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23."Gene 217:107-116(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Alterations of the PPP2R1B gene in human lung and colon cancer."Science 282:284-287(1998) [PubMed] [Europe PMC] [Abstract]
  3. "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region."Eur. J. Hum. Genet. 9:121-129(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure."Biochemistry 29:3166-3173(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation."J. Biol. Chem. 275:22300-22304(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction between protein phosphatase 2A and members of the importin beta superfamily."Biochem. Biophys. Res. Commun. 303:908-913(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Absence of PPP2R1B gene alterations in primary ovarian cancers."Oncogene 18:6367-6369(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers."Gut 47:268-271(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas."Cancer Genet. Cytogenet. 134:13-17(2002) [PubMed] [Europe PMC] [Abstract]