≡

Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4)

[Edit]

PP2A; PR53; PTPA; Phosphotyrosyl Phosphatase Activator; PP2A Phosphatase Activator; PP2A, subunit B', PR53 isoform; Serine/threonine-protein phosphatase 2A activator

Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4)
CCC E026
HGNC 9308
MGI 1346006
PubMed 22892532
RGD 1308354
UniProt Q15257
Wiki PPP2R4
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. PPP2R4 encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE026Ra01 Recombinant Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE026Ra21 Monoclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) WB; IHC; ICC; IP.
PAE026Ra01 Polyclonal Antibody to Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) WB; IHC; ICC; IP.
Assay Kits SEE026Ra ELISA Kit for Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A."J. Biol. Chem. 269:15668-15675(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A."Genomics 28:261-272(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene."Eur. J. Biochem. 267:4406-4413(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis."Apoptosis 12:1243-1255(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions."J. Biol. Chem. 281:22434-22438(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity."Mol. Cell 23:413-424(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Structure and mechanism of the phosphotyrosyl phosphatase activator."Mol. Cell 23:535-546(2006) [PubMed] [Europe PMC] [Abstract]