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Protein Phosphatase 4, Catalytic Subunit (PPP4C)

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PP4; PPH3; PPX; Protein phosphatase X; Serine/threonine-protein phosphatase 4 catalytic subunit

Protein Phosphatase 4, Catalytic Subunit (PPP4C)
CCC E034
HGNC 9319
MGI 1891763
PubMed 18487071
RGD 621225
UniProt P60510
Wiki PPP4C
Protein phosphatases are involved in determining the phosphorylation state of many regulatory proteins. Other members of this family include PP1 , PP2A, and PP5 .
HDAC3 copurified with PPP4C and its regulatory subunit, PPP4R1, in an HDAC3 complex that showed phosphatase activity. Both PP4 proteins interacted directly with HDAC3, and mutation analysis indicated that the N terminus of HDAC3 was necessary and sufficient for HDAC3-PPP4C interaction. Both overexpression and RNA interference experiments indicated that HDAC3 activity was inversely proportional to the cellular abundance of PPP4C.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Catalytic Subunit (PPP4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Catalytic Subunit (PPP4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Catalytic Subunit (PPP4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Catalytic Subunit (PPP4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Catalytic Subunit (PPP4C) ELISA Kit Customized Service Offer
  1. "Protein phosphatase X has been highly conserved during mammalian evolution."Biochim. Biophys. Acta 1171:231-233(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity."J. Biol. Chem. 273:33561-33565(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase."J. Biol. Chem. 277:6391-6398(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Functional expression cloning reveals proapoptotic role for protein phosphatase 4."Cell Death Differ. 10:1016-1024(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs."J. Cell Sci. 116:1905-1913(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation."J. Biol. Chem. 279:46588-46594(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4."Genes Dev. 19:827-839(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
  10. "PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint."EMBO Rep. 9:1019-1026(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases."Int. J. Biochem. Cell Biol. 40:2315-2332(2008) [PubMed] [Europe PMC] [Abstract]
  12. "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4."J. Biol. Chem. 283:29273-29284(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation."J. Cell Biol. 180:1133-1147(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication."Mol. Cell 31:33-46(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination."Nat. Struct. Mol. Biol. 17:365-372(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions."Biochem. Biophys. Res. Commun. 452:42-47(2014) [PubMed] [Europe PMC] [Abstract]