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Protein Phosphatase 5, Catalytic Subunit (PPP5C)

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PP5; PPP5; PPT; Protein phosphatase T; Serine/threonine-protein phosphatase 5

Protein Phosphatase 5, Catalytic Subunit (PPP5C)
CCC E035
HGNC 9322
MGI 102666
PubMed 22526606
RGD 68415
UniProt P53041
Wiki PPP5C
A variety of biologic processes, such as cell signaling, transcription, and mitosis, are regulated by reversible protein phosphorylation at serine and threonine residues. The serine/threonine kinases are responsible for phosphorylation and the phosphatases are required for dephosphorylation. The PP5 cDNA was isolated by screening a human teratocarcinoma cDNA library at low stringency with a PP2B probe. By Northern blotting they observed a 2.3-kb mRNA in all tissues they examined. The predicted PP5 protein shares about 35 to 40% identity with other members of the superfamily and the N-terminal domain contains tetratricopeptide-like repeats found in several nuclear regulatory proteins. Recombinant PP5 was able to dephosphorylate serine residues and was shown to be sensitive to the tumor promoter okadaic acid.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 5, Catalytic Subunit (PPP5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 5, Catalytic Subunit (PPP5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 5, Catalytic Subunit (PPP5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 5, Catalytic Subunit (PPP5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 5, Catalytic Subunit (PPP5C) ELISA Kit Customized Service Offer
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  10. "DNA-PKcs function regulated specifically by protein phosphatase 5."Proc. Natl. Acad. Sci. U.S.A. 101:1247-1252(2004) [PubMed] [Europe PMC] [Abstract]
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  12. "Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease."J. Biol. Chem. 280:1790-1796(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Protein phosphatase 5 is required for ATR-mediated checkpoint activation."Mol. Cell. Biol. 25:9910-9919(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5."Nat. Cell Biol. 8:1011-1016(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."Proc. Natl. Acad. Sci. U.S.A. 103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage."J. Biol. Chem. 284:9845-9853(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro."J. Biol. Chem. 285:3872-3882(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Protein phosphatase 5 is necessary for ATR-mediated DNA repair."Biochem. Biophys. Res. Commun. 404:476-481(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."Cell. Signal. 24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]
  23. "S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation."J. Biol. Chem. 287:13787-13798(2012) [PubMed] [Europe PMC] [Abstract]
  24. "The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5."Mol. Cell 48:692-704(2012) [PubMed] [Europe PMC] [Abstract]
  25. "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions."EMBO J. 17:1192-1199(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5."J. Biol. Chem. 279:33992-33999(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Molecular basis for TPR domain-mediated regulation of protein phosphatase 5."EMBO J. 24:1-10(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90."Structure 14:415-426(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin."J. Med. Chem. 52:4838-4843(2009) [PubMed] [Europe PMC] [Abstract]