Protocadherin Gamma C4 (PCDHgC4)

PCDHGC4 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain .

Sequence analysis predicted that the 938-amino acid PCDHGC4 protein is 48% identical to PCDHGA3 . The C-terminal 134 amino acids of PCDHGC4 and PCDHGA3 are identical and have a lysine-rich motif. PCDHGC4 has a signal peptide, 2 putative N-linked glycosylation sites, 6 cadherin ectodomains, a transmembrane segment, and a cytoplasmic domain.