Protocadherin Alpha 13 (PCDHa13)

PCDHA13 is 1 of 15 tandemly arranged genes within the PCDHA gene cluster on chromosome 5q31. The 15 PCDHA genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHA transcripts. These transcripts encode cadherin-like cell surface proteins that are expressed in neurons and are present at synaptic junctions (Ribich et al., 2006). For further information on the PCDHA genes. By genomic sequence analysis, Wu et al. (2001) mapped the PCDHA13 gene to chromosome 5q31. They localized the mouse PCDHA genes to chromosome 18c. Eight promoter-hypermethylated genes (ANKDD1A, GAD1, HIST1H3E, PCDHA8, PCDHA13, PHOX2B, SIX3, and SST) were confirmed in primary glioma and cell lines.