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Protocadherin 15 (PCDH15)

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USH1F; DFNB23; CDHR15; Deafness,Autosomal Recessive 23; Cadherin-Related Family Member 15

Protocadherin 15 (PCDH15)
CCC E095
HGNC 14674
MGI 1891428
PubMed 11398101
RGD 1590969
UniProt Q96QU1
Wiki PCDH15
PCSH15 encodes a variety of isoforms with 3 to 11 ectodomains, a transmembrane domain, and a C-terminal cytoplasmic domain (CD). The amino acid sequences of CD1, CD2, and CD3 are entirely different. PCDH15-CD1 showed a limited pattern of expression and was detected in human testis, retina, and cochlea. PCDH15-CD2 expression was present in the human heart, kidney, thymus, spleen, testis, retina and cochlea. PCDH15-CD3 was widely transcribed and detected in almost all of 18 tissues tested. PCDH15 expression in the inner and outer synaptic layers and the nerve fiber layer in human adult and fetal retinas. Additional reactivity in the region of the outer limiting membrane/photoreceptor cell inner segments was observed in adult but not fetal retina.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE095Hu01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE095Hu01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
MAE095Hu21 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
Assay Kits SEE095Hu ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE095Mu01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
RPE095Mu02 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE095Mu01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB,IHC
PAE095Mu02 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
Assay Kits SEE095Mu ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protocadherin 15 (PCDH15) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protocadherin 15 (PCDH15) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protocadherin 15 (PCDH15) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protocadherin 15 (PCDH15) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protocadherin 15 (PCDH15) ELISA Kit Customized Service Offer
  1. "Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F."Hum. Mol. Genet. 10:1709-1718(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F."Am. J. Hum. Genet. 69:25-34(2001) [PubMed] [Europe PMC] [Abstract]
  3. "PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23."Hum. Mol. Genet. 12:3215-3223(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Gene structure and mutant alleles of PCDH15: nonsyndromic deafness DFNB23 and type 1 Usher syndrome."Hum. Genet. 124:215-223(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas."Oncogene 25:2807-2811(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population."Hum. Genet. 116:292-299(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans."Hum. Mol. Genet. 14:103-111(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Mutation screening of the PCDH15 gene in Spanish patients with Usher syndrome type I."Mol. Vis. 18:1719-1726(2012) [PubMed] [Europe PMC] [Abstract]