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Ephrin B1 (EFNB1)

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CFND; CFNS; EFL3; EPLG2; Elk-L; LERK2; EPH-related receptor tyrosine kinase ligand 2; Craniofrontonasal Syndrome(Craniofrontonasal Dysplasia)

Ephrin B1 (EFNB1)
CCC E114
HGNC 3226
MGI 102708
PubMed 15959873
RGD 2540
UniProt P98172
Wiki EFNB1
Ephrin-B1 is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.Disruption of EphB2 and EphB3 genes revealed that their gene products restrict cell intermingling and allocate cell populations within the intestinal epithelium. In EphB2/EphB3 null mice, the proliferative and differentiated populations intermingled. In adult EphB3 -/- mice, Paneth cells did not follow their downward migratory path, but scattered along crypt and villus. The authors concluded that, in the intestinal epithelium, beta-catenin and TCF couple proliferation and differentiation to the sorting of cell populations through the EphB/ephrin B system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE114Hu01 Recombinant Ephrin B1 (EFNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE114Hu21 Monoclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
PAE114Hu01 Polyclonal Antibody to Ephrin B1 (EFNB1) WB; IHC; ICC; IP.
Assay Kits SEE114Hu ELISA Kit for Ephrin B1 (EFNB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin B1 (EFNB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin B1 (EFNB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin B1 (EFNB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin B1 (EFNB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin B1 (EFNB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin B1 (EFNB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin B1 (EFNB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin B1 (EFNB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin B1 (EFNB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin B1 (EFNB1) ELISA Kit Customized Service Offer
  1. "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors."EMBO J. 13:3757-3762(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity."Science 266:816-819(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains."Neuron 22:511-524(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4."BMB Rep. 44:199-204(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome."Am. J. Hum. Genet. 74:1209-1215(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome."Proc. Natl. Acad. Sci. U.S.A. 101:8652-8657(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Twenty-six novel EFNB1 mutations in familial and sporadic craniofrontonasal syndrome (CFNS)."Hum. Mutat. 26:113-118(2005) [PubMed] [Europe PMC] [Abstract]