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Ephrin Type B Receptor 2 (EPHB2)

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CAPB; DRT; EPHT3; ERK; Hek5; PCBC; Tyro5; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH-like kinase 5; EPH tyrosine kinase 3

Ephrin Type B Receptor 2 (EPHB2)
CCC E117
HGNC 3393
MGI 99611
PubMed 16049340
RGD 1564232
UniProt P29323
Wiki EPHB2
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins.
The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EPHB2 is a receptor for ephrin-B family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE117Hu01 Recombinant Ephrin Type B Receptor 2 (EPHB2) Positive Control; Immunogen; SDS-PAGE; WB.
RPE117Hu02 Recombinant Ephrin Type B Receptor 2 (EPHB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 2 (EPHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 2 (EPHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 2 (EPHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 2 (EPHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 2 (EPHB2) ELISA Kit Customized Service Offer
  1. "Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors."Cancer Res. 54:3645-3650(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family."Hum. Mol. Genet. 4:2033-2045(1995) [PubMed] [Europe PMC] [Abstract]
  3. "A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals."Oncogene 17:521-526(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases."Oncogene 10:897-905(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the human ERK gene as a putative receptor tyrosine kinase and its chromosomal localization to 1p36.1: a comparative mapping of human, mouse, and rat chromosomes."Genomics 26:382-384(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer."Biochem. Biophys. Res. Commun. 194:698-705(1993) [PubMed] [Europe PMC] [Abstract]
  8. "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases."Oncogene 6:1057-1061(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Oligomeric structure of the human EphB2 receptor SAM domain."Science 283:833-836(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition."J. Biol. Chem. 282:36505-36513(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer." Nat. Genet. 36:979-983(2004) [PubMed] [Europe PMC] [Abstract]
  16. "A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history."J. Med. Genet. 43:507-511(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]