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Ephrin Type B Receptor 4 (EPHB4)

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HTK; MYK1; TYRO11; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11

Ephrin Type B Receptor 4 (EPHB4)
CCC E119
HGNC 3395
MGI 104757
PubMed 16816380
UniProt P54760
Wiki EPHB4
Ephrin type-B receptor 4 is a protein encoded by the EPHB4 gene.Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 4 (EPHB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 4 (EPHB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 4 (EPHB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 4 (EPHB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 4 (EPHB4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type B Receptor 4 (EPHB4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type B Receptor 4 (EPHB4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type B Receptor 4 (EPHB4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type B Receptor 4 (EPHB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type B Receptor 4 (EPHB4) ELISA Kit Customized Service Offer
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  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
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  14. "Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity."J. Biol. Chem. 281:28185-28192(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity."Structure 14:321-330(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the second FN3 domain from human ephrin type-B receptor 4."Submitted (JUL-2007) to the PDB data bank
  17. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]