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Ephrin Type A Receptor 4 (EPHA4)

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HEK8; SEK; TYRO1; EPH-like kinase 8; Tyrosine-protein kinase receptor SEK

Ephrin Type A Receptor 4 (EPHA4)
CCC E124
HGNC 3388
MGI 98277
PubMed 22922411
RGD 1560587
UniProt P54764
Wiki EPHA4
EPH receptor A4 is a protein belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE124Hu01 Recombinant Ephrin Type A Receptor 4 (EPHA4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE124Hu01 Polyclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) WB; IHC; ICC; IP.
MAE124Hu21 Monoclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) WB; IHC; ICC; IP.
Assay Kits SEE124Hu ELISA Kit for Ephrin Type A Receptor 4 (EPHA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 4 (EPHA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 4 (EPHA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 4 (EPHA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ephrin Type A Receptor 4 (EPHA4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ephrin Type A Receptor 4 (EPHA4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ephrin Type A Receptor 4 (EPHA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ephrin Type A Receptor 4 (EPHA4) ELISA Kit Customized Service Offer
  1. "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases."Oncogene 10:897-905(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."J. Neurosci. 27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor."J. Biol. Chem. 283:29473-29484(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."Structure 17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."J. Biol. Chem. 285:644-654(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]