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Defensin Alpha 4, Corticostatin (DEFa4)

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DEF4; HP-4; HNP-4; Neutrophil defensin 4

Defensin Alpha 4, Corticostatin (DEFa4)
CCC E137
HGNC 2763
PubMed 20016407
UniProt P12838
Wiki DEFA4
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region.DEFa4 is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.The nucleotide sequence shares about 72% identity with the cDNA encoding defensin HP-1 , but differed from it and from other genes of this family by an extra 83-base segment. This extra segment was not adjacent to an intron and was apparently the result of a recent duplication within the coding region corresponding to most of the mature HP-4 peptide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE137Hu01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE137Hu21 Monoclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
PAE137Hu01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
Assay Kits SEE137Hu ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE137Mu01 Recombinant Defensin Alpha 4, Corticostatin (DEFa4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE137Mu01 Polyclonal Antibody to Defensin Alpha 4, Corticostatin (DEFa4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Defensin Alpha 4, Corticostatin (DEFa4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defensin Alpha 4, Corticostatin (DEFa4) ELISA Kit Customized Service Offer
  1. "The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8."Mol. Endocrinol. 7:199-205(1993) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of a novel human granulocyte peptide with anti-ACTH activity."Biochem. Biophys. Res. Commun. 155:524-529(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family."J. Biol. Chem. 264:11200-11203(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Antibacterial activity and specificity of the six human alpha-defensins."Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro."FEBS Lett. 579:162-166(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structures of human alpha-defensins HNP4, HD5, and HD6."Protein Sci. 15:2749-2760(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]