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Gamma-Glutamyltransferase 2 (gGT2)

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GGT; Glutathione hydrolase 2; Inactive gamma-glutamyltranspeptidase 2

Gamma-Glutamyltransferase 2 (gGT2)
CCC E141
HGNC 4251
PubMed 23682772
UniProt P36268
GGT2 belongs to the gamma-glutamyltransferase (GGT) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis.
The confusion between type II GGT mRNA and GGT2 arose from the nonstandardized nomenclature of GGT isoforms, genes, and mRNAs. There is a marked heterogeneity in GGT in human serum and tissues, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. Heterogeneity in human serum is also related to association of GGT with various other proteins .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamyltransferase 2 (gGT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamyltransferase 2 (gGT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamyltransferase 2 (gGT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamyltransferase 2 (gGT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamyltransferase 2 (gGT2) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney."Biochem. Biophys. Res. Commun. 164:912-918(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling."Antioxid. Redox Signal. 19:1877-1888(2013) [PubMed] [Europe PMC] [Abstract]