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Adenosine Deaminase, RNA Specific (ADAR)

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ADAR1; DRADA; DSH; DSRAD; G1P1; IFI4; p136; Interferon-Induced Protein 4; 136 kDa double-stranded RNA-binding protein; Double-stranded RNA-specific adenosine deaminase

Adenosine Deaminase, RNA Specific (ADAR)
CCC E154
HGNC 225
MGI 1889575
PubMed 21728134
RGD 71099
UniProt P55265
Double-stranded RNA-specific adenosine deaminase is an enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.ADAR requires the small molecule inositol hexakisphosphate (IP6) for proper function. Ubiquitously expressed, highest levels were found in brain and lung.SH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE154Hu01 Recombinant Adenosine Deaminase, RNA Specific (ADAR) Positive Control; Immunogen; SDS-PAGE; WB.
RPE154Hu02 Recombinant Adenosine Deaminase, RNA Specific (ADAR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE154Hu01 Polyclonal Antibody to Adenosine Deaminase, RNA Specific (ADAR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Adenosine Deaminase, RNA Specific (ADAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine Deaminase, RNA Specific (ADAR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosine Deaminase, RNA Specific (ADAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosine Deaminase, RNA Specific (ADAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine Deaminase, RNA Specific (ADAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine Deaminase, RNA Specific (ADAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine Deaminase, RNA Specific (ADAR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosine Deaminase, RNA Specific (ADAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosine Deaminase, RNA Specific (ADAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine Deaminase, RNA Specific (ADAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine Deaminase, RNA Specific (ADAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine Deaminase, RNA Specific (ADAR) ELISA Kit Customized Service Offer
  1. "Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing."Proc. Natl. Acad. Sci. U.S.A. 91:11457-11461(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase."Mol. Cell. Biol. 15:5376-5388(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase."J. Biol. Chem. 272:4419-4428(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible."Proc. Natl. Acad. Sci. U.S.A. 96:4621-4626(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA."J. Biol. Chem. 278:17093-17102(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Dynamic association of RNA-editing enzymes with the nucleolus."J. Cell Sci. 116:1805-1818(2003) [PubMed] [Europe PMC] [Abstract]
  10. "ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells."J. Biol. Chem. 280:3946-3953(2005) [PubMed] [Europe PMC] [Abstract]
  11. "New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1."J. Virol. 79:6291-6298(2005) [PubMed] [Europe PMC] [Abstract]
  12. "SUMO-1 modification alters ADAR1 editing activity."Mol. Biol. Cell 16:5115-5126(2005) [PubMed] [Europe PMC] [Abstract]
  13. "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing."Mol. Cell. Biol. 25:6956-6963(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The large form of ADAR 1 is responsible for enhanced hepatitis delta virus RNA editing in interferon-alpha-stimulated host cells."J. Viral Hepat. 13:150-157(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection."J. Virol. 81:917-923(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation."J. Biol. Chem. 283:7251-7260(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus."Proc. Natl. Acad. Sci. U.S.A. 105:5028-5033(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  23. "RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR."J. Biol. Chem. 284:29350-29356(2009) [PubMed] [Europe PMC] [Abstract]
  24. "ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication."J. Virol. 83:10119-10128(2009) [PubMed] [Europe PMC] [Abstract]
  25. "RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1."Mol. Cell. Biol. 29:1487-1497(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection."Nucleic Acids Res. 37:5848-5858(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Functions and regulation of RNA editing by ADAR deaminases."Annu. Rev. Biochem. 79:321-349(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Human BLCAP transcript: new editing events in normal and cancerous tissues."Int. J. Cancer 127:127-137(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "RNA editing catalyzed by ADAR1 and its function in mammalian cells."Biochemistry (Mosc.) 76:900-911(2011) [PubMed] [Europe PMC] [Abstract]
  33. "ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor."J. Gen. Virol. 92:1228-1232(2011) [PubMed] [Europe PMC] [Abstract]
  34. "Adenosine deaminases acting on RNA, RNA editing, and interferon action."J. Interferon Cytokine Res. 31:99-117(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase."J. Virol. 85:8460-8466(2011) [PubMed] [Europe PMC] [Abstract]
  36. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral."Virology 411:180-193(2011) [PubMed] [Europe PMC] [Abstract]
  38. "A-to-I editing of protein coding and noncoding RNAs."Crit. Rev. Biochem. Mol. Biol. 47:493-501(2012) [PubMed] [Europe PMC] [Abstract]
  39. "ADAR proteins: structure and catalytic mechanism."Curr. Top. Microbiol. Immunol. 353:1-33(2012) [PubMed] [Europe PMC] [Abstract]
  40. "Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus."J. Virol. 86:3787-3794(2012) [PubMed] [Europe PMC] [Abstract]
  41. "Activity regulation of adenosine deaminases acting on RNA (ADARs)."Mol. Neurobiol. 45:61-75(2012) [PubMed] [Europe PMC] [Abstract]
  42. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  43. "Crystal structure of the Z alpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA."Science 284:1841-1845(1999) [PubMed] [Europe PMC] [Abstract]
  44. "The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA."Proc. Natl. Acad. Sci. U.S.A. 96:12465-12470(1999) [PubMed] [Europe PMC] [Abstract]
  45. "Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria."Am. J. Hum. Genet. 73:693-699(2003) [PubMed] [Europe PMC] [Abstract]
  46. "Seven novel mutations of the ADAR gene in Chinese families and sporadic patients with dyschromatosis symmetrica hereditaria (DSH)."Hum. Mutat. 23:629-630(2004) [PubMed] [Europe PMC] [Abstract]
  47. "A new arginine substitution mutation of DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditaria."J. Dermatol. Sci. 37:95-99(2005) [PubMed] [Europe PMC] [Abstract]
  48. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  49. "Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature." Nat. Genet. 44:1243-1248(2012) [PubMed] [Europe PMC] [Abstract]